The Renal Tubular Epithelial Cells would have secreting function when the phenotype of them turns into Cyst Epithelial Cells. Because the cells secrete more and more liquid without normal excretion pathway as the growth of the age, lots of Cyst Fluid is accumulated there. And this results in the enlargement of the cysts, the rise of the pressure in the cysts and the increase of surface tension of it. At this time some sensitive patients would have lumbar unwell and feel sore and bursting. And when part of the cysts is infected, patients would be painful. By the gradual increase of the cysts, the normal structure of the kidney would be replaced, and the function of the kidney begin to decline gradually, which results in Hypertension and abnormal result in test of Urine Routine and renal function.
There are some rules in each Polycystic Kidney Disease stage:
A. Emergence period: the disease is a kind of hereditary disease, and patients always have the cysts inborn which are just too small to be checked out at early stage and it is generally difficult to check out the cysts before the 20s of the patient. If there are the cases of Polycystic Kidney Disease in their family, people should take the examination as early as possible to observe the growth state of the cysts. And they need to take good care of their body.
B. Growth stage: There would be a rapid growth of the cysts when the patient are at the age of 30s to 40s. And we call this period as the growth stage medically. It should be given close observation in growth period. But Western doctors have no method of treatment in this period and they believe the treatment is unnecessary, so what they do is just to conduct symptomatic treatment such as Hypertension and so on, which is quite passive. Patients should positively conduct treatment in this period to stop or slow the cysts’ growth rate by applying the Chinese medicine with the stronger effect of promoting blood circulation and removing blood stasis. And this would meet the purpose to extend the lifetime of the patients. We believe the period is the critical period to slow the growth rate of the cysts by using the Chinese medicine with the effect of promoting blood circulation and removing blood stasis.
C. The swelling period: the cysts would further grow and swell when the patient is in his 40s. In this period the cysts is more than 4cm in size and begin to break up. We call this period as the swelling period. By the enlargement of the cysts, there would be more clinical symptoms such as backache, albuminuria, blood urine, and the increase of blood pressure. We should observe closely in this period. And this period is also the critical period for treament combined with traditional Chinese and western medicine. We could use Chinese medicine to promote blood circulation and remove blood stasis and discharge the toxin of the body, in essence we protect the renal function by getting rid of the cysts liquid which is harmful to the renal function. So the swelling period of Polycystic Kidney is the critical time for the protection of renal function through combined treatment of traditional Chinese medicine and western.
