What is the high serum creatinine of reason?
The experts pointed out: kidney patients in the clinical examination, there will be fluctuations of creatinine, the performance of higher than normal for serum creatinine, urine creatinine lower than normal. This is due to the kidney by the various causes of violations of the first impaired renal inherent cell phenotypic transition occurs, the formation of pathological changes, stimulate kidney fibroblasts into myofibroblasts, violated and stimulate the inherent normal kidney tissue, the occurrence of the same disease, thus forming a kidney from point to plane, from the local to the overall expansion of the excitation spread process, to enter the device matter injury period (ie, renal injury period), this time due to kidney damage and excrete waste function is decreased, causing the aggregation of serum creatinine and other toxins in the body, and thus give rise to serum creatinine, blood urea nitrogen increased, and urine creatinine decreased kidney filtration rate.
Serum creatinine, also known as serum creatinine
Clinical detection of serum creatinine is one of the main methods for common understanding of renal function. Creatinine is how it all about? Endogenous creatinine is a product of the metabolism of human muscle. In muscle, creatine is mainly by the irreversible non-enzymatic dehydration reaction slowly formed creatinine, and then released into the bloodstream, with the urinary excretion. Serum creatinine and total body muscle are closely related and difficult to influence by diet. Creatinine small molecules, very little absorption by glomerular filtration in the renal tubules, creatinine, daily body produces almost all of the urine, usually from urine affect.
Which diseases cause the serum creatinine high?
An existing high blood pressure, blood pressure not controlled, long-term, medium and massive proteinuria (24 hour total urinary protein greater than 1 g or 1.5 g), can slow progress unknowingly elevated serum creatinine.
Existing renal insufficiency, such as co-infection, including colds, pneumonia, intestinal infections, urinary tract infections such as elevated serum creatinine in the short term.
Body water loss, such as fever, sweating, reduced water intake, polyuria of the blood concentration, the reduction in renal blood flow, elevated serum creatinine.
The original kidney disease patients, relapse, oliguria, and even urine, can be combined acute renal failure, resulting in serum creatinine increased.
The original kidney disease patients, the use of drugs damage the kidneys, and can appear elevated serum creatinine, even irreversible.
6. Life tired, resting well, the details of life do not pay attention, can also cause elevated serum creatinine.
