Kidney disease patients are confused why they have decreased GFR already but the creatinine is normal.
Creatinine is the metabolin of human muscle, and every 20g muscle metabolin can produce 1 mg creatinine. Creatinine is discharged mainly by glomerulus. The concentration change of serum creatinine is determined by glomerulus filtration ability(GFR). If filtration ability decrease, the creatinine concentration will increase. Serum creatinine is higher than the normal level, which means the kidney gets damaged. Please notice that only GFR reduce to 1/3 of normal level, serum creatinine begins to increase obviously.
The reason why patients present this phenomenon is because that kidney has strong metabolic capacity, patients don’t have obvious discomfort if kidney has light damage, but when patients present the symptoms like edema,vomiting,dizzy etc, that means the kidney has already get damged seriously, and serum creatinine begin to increase obviously.
