The pathological changes of PKD are: autosome dominant inheritance transformed the phenotype of the epithelial cells in nephridial tubule into epithelial cells in cyst wall. Constantly sac liquid made the cysts become bigger and bigger, and then the normal structure in the kidney be replaced by the cysts, the parclose function of glomerulus decreases as well as the concentration, reabsorption, regulation function in nephridial tubule. Therefore, we can find some signs such as protein and occult blood when we do routine urinalysis, and PKD is in fact a kind of Renal Tubular Epithelial Cell Disease.
