What is SLE

Induced by environmental factors or a number of aggravate SLE external factors including chronic infection, drugs, physical factors of emotional stimuli living environment and so is more important. Chronic infection common chronic virus infection in the tissue of patients with SLE found under the electron microscope tube reticular inclusion bodies and the nucleoprotein of paramyxovirus and core of the tubular structure is similar, but further studies suggest that this is a non-specific kind of cell damage performance. It was also from glomerular endothelial cells in patients with SLE plasma, vascular endothelial cells, skin lesions have been found similar inclusion body material. However, including the organization of the inclusion body-like substance have not been able to isolate virus, these substances and virus infection is yet to be confirmed in patients with SLE, there are a variety of high titers of anti-viral antibodies such as anti-measles, anti-rubella, anti-vice influenza, anti-Epstein-Barr virus anti-mumps, anti-stick virus antibodies. The incidence of C-type RNA virus closely related to ds-DNA, the dsRNA and RNA-DNA anti-retroviral antibodies were also raised in SLE Generally speaking, many indications in the serum of patients with viral infections may be of SLE one of the causes, but not yet confirmed the virus infection and patients with SLE, the immune dysregulation and the occurrence of autoimmune addition, also suggested that the pathogenesis of SLE with tuberculosis or streptococcal infection. Drugs to a variety of drugs and pathogenesis of SLE, but the pathogenic mechanisms vary. (1) drug-induced SLE symptoms penicillin, sulfonamides, phenylbutazone, gold preparations. These drugs into the body, the first cause allergy and then stimulate the of lupus quality or the potential incidence of SLE patients, or with SLE who exacerbations, withdrawal can not prevent the progression of the disease. The ② trigger lupus-like syndrome, drug hydralazine, procainamide, chlorpromazine and phenytoin, isoniazid propyl and oxygen (methylthio) pyrimidine.These drugs for a long time after the use of large doses, the patient can occur in SLE clinical symptoms and laboratory changes, but the pathogenesis is not yet clear. Some people think that chlorpromazine soluble nuclear protein binding to enhance their immunity after UV irradiation and hydralazine combination with the soluble protein in the body can enhance the immunogenicity of the composition of. Such patients after discontinuation symptoms can subside on their own or residue few symptoms subside with the continuous emergence of new drugs was also suggested that the drug can be used as the exogenous vector, epitope combination, induced autoantibodies with the host tissue to produce a result, the clinical use The drug should pay attention to the occurrence of drug-induced lupus. Physical factors about 1/3 of SLE patients to sunlight allergy, UV-induced skin lesions or the original lesions exacerbate the small number of cases and can precipitate or aggravate systemic disease. Double-stranded DNA in normal skin tissue after exposure to ultraviolet light dimerization occurs, the formation of thymine dimers, while removal of repairable after UV irradiation in patients with SLE in depolymerization dimerization DNA repair defects, excessive thymus pyrimidine dimers may be the pathogenic antigen. Also suggested that ultraviolet radiation can make the skin cells are damaged, anti-nuclear factor to enter the cell, play a role with the nucleus, resulting in skin damage, X-ray irradiation, cold, strong electro-optical radiation can trigger or aggravate SLE disease. Eating foods containing psoralens, such as celery, figs, parsnips, etc., with enhanced light-sensitive potential role of SLE patients; containing hydrazine gene mushrooms, smoked foods, food dyes, and tobacco can be induced by drugs lupus; containing L-concanavalin alfalfa class seed sprouts and other legumes can also be induced lupus. Caloric restriction and fatty acid intake can reduce the severity of the mouse lupus speculated that this may benefit patients with SLE. Other asbestos-silica, vinyl chloride and containing reactive aromatic amine dyes which may be related to the pathogenesis of SLE. Serious physical, psychological stress can be induced by the sudden onset of SLE. Endocrine factors SLE mainly involving women, the prevalence of women of reproductive age 9 to 13 times higher than their male counterparts, but the pre-adolescent and post-menopausal women the prevalence was only slightly higher than the male. It is felt that estrogen and SLE related to the occurrence. Whether male or female patients with SLE 16α-hydroxylation of estrone and estriol water were significantly higher. The female birth control pills sometimes can trigger lupus-like syndrome. Human and animal studies have demonstrated that estrogen can increase the B cells to produce antibodies against DNA, and androgens can inhibit such a response, recently found in SLE serum prolactin increased, resulting in secondary changes in sex hormones, this needs to be confirmed by further studies.