What is the reason for anemia with ESRD patinets

The main component of RBC hemoglobin. Hemoglobin is composed of protein and iron in the synthesis process also requires maintenance bovine hormone c and Vitamin B: participation. Bone alkaline place of the red blood cell synthesis. Entire generation process of the red blood cells, including the synthesis of hemoglobin, the red blood cells of mature kidneys secrete erythropoietin factor and red blood cell known as a very close ... to generate ESRD anemia following detailed the introduction:
The main component of RBC hemoglobin. Hemoglobin is composed of protein and iron in the synthesis process also requires maintenance bovine hormone c and Vitamin B: participation. Bone alkaline place of the red blood cell synthesis. Entire generation of red blood cells, including the synthesis of hemoglobin, red blood cells mature, with the kidneys secrete erythropoietin factor and the red blood cells to generate known as a very close relationship. Specifically, the ESRD anemia mainly due to the following aspects.
(1) lack of nutrition: reduce chronic renal failure patients with long-term low-protein diet, protein synthesis in the body, but there are large numbers of protein loss in the urine, together with patients with symptoms of anorexia. Intestinal absorption function is not a good result, blood raw ( such as iron, folic acid, protein) intake. These factors will inevitably patients with malnutrition leading to anemia.
(2) erythropoietin decreased: in ESRD, causing serious damage to the renal parenchyma, the kidney erythropoietin factor and erythropoietin reduce erythropoietin stimulation of bone marrow was weakened red blood cell production and mature obstacles therefore appear progressive anemia.
Accelerated destruction of red blood cells (3): chronic renal failure, the body of metabolic wastes (such as methyl clothing) from the urine decreased. Concentration in the blood, such substances can accelerate the destruction of red blood cells, the red blood cells shortened life expectancy . caused hemolysis.
(4) chronic blood loss: melons substances and phenols in the blood of patients with renal failure can not be from the urine, one hand, these substances can cause coagulation abnormalities; They also enable the wool sewing vascular fragility. Because of the role of these toxic substances, many patients with end stage renal disease often epistaxis, teeth bowel bleeding, subcutaneous bleeding and gastrointestinal bleeding. These also cause anemia reasons. Anemia caused by renal parenchymal disease called renal anemia. The nature of iron deficiency anemia or small cell hypochromic anemia. More severe renal failure, anemia is more powerful.