High Blood Pressure and Kidney Disease

Blood pressure measures the force of blood against the walls of your blood vessels. Blood pressure that remains high over time is called hypertension. Extra fluid in your body increases the amount of fluid in your blood vessels and makes your blood pressure higher. Narrow or clogged blood vessels also raise your blood pressure.
High blood pressure makes your heart work harder and, over time, can damage blood vessels throughout your body. If the blood vessels in your kidneys are damaged, they may stop removing wastes and extra fluid from your body. The extra fluid in your blood vessels may then raise blood pressure even more. It's a dangerous cycle.
High blood pressure is one of the leading causes of kidney failure, also commonly called end-stage renal disease (ESRD). People with kidney failure must either receive a kidney transplant or go on dialysis. Every year, high blood pressure causes more than 25,000 new cases of kidney failure in the United States.
Every year, high blood pressure causes more than 25,000 new cases of kidney failure in the United States.
Chronic kidney disease (CKD) is present when the estimated glomerular filtration rate (eGFR) is below 60 milliliters per minute (mL/min).
More than 30 milligrams of albumin per gram of creatinine in a urine sample is another sign of CKD.
People with CKD should try to keep their blood pressure below 130/80.
Two groups of medicines called angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) lower blood pressure and have an added protective effect on the kidneys.
African Americans are six times more likely than Caucasians to develop hypertension-related kidney failure.
Early management of high blood pressure is especially important for African Americans with diabetes.

The hazards of Chronic Nephropathy

Patients with chronic kidney disease is a variety of symptoms, the symptoms of edema and hypertension are more common, however, the most obvious is the most harmful is proteinuria. Such symptoms with the naked eye can not see, and this symptom treatment is more troublesome.
Proteinuria, although not particularly obvious, but if it is chronic kidney disease must check whether the emergence of such symptoms, and should make the treatment measures in a timely manner. Chronic kidney disease proteinuria is not only a sign of kidney damage, a large number of proteins by tubular excretion will trigger the inflammation and fibrosis of the renal tubular epithelial cells, thus accelerating the development of chronic kidney disease. Recent studies have confirmed that a large number of urinary protein to promote the progress of chronic kidney disease to one of the major risk factor for end-stage renal failure, and should therefore be used as the important goal of the treatment of chronic kidney disease. Glomerular mesangial toxicity of the urine protein: proteinuria nephropathy model, low-density lipoprotein (LDL) and very low density lipoprotein (VLDL) apolipoprotein B and apolipoprotein A deposition gathered eventually be leading to glomerular sclerosis. Urinary protein toxic effects on proximal tubule cells: proteinuria, enter the amount of protein within the renal tubular epithelial cells to increase, so that the increase of lysosomal activity, suggesting that the protein caused lysosomal spilled into the small tube cytoplasm, followed by cell damagecan stimulate inflammation and scar formation.
Weifang, Shandong Red Sun nephropathy hospital experts pointed out that the protein in the urine of chronic kidney disease often make friends of patients are not very understanding, but also often ignore the dangers of tubule cell biological changes caused by the urine protein is a very serious and urine protein many kidney disease there is excessive proliferation of cells, represents a non-adaptive responses, leading to renal failure. More and more evidence to show that the protein can be directly conditioning tubule cell function, to change its growth characteristics of cytokines and matrix proteins phenotypic expression, the basal side of the tubule can lead to release of PDGF, FN and MCP-1 induced fibrosis. The urine protein to cause tubulointerstitial hypoxia aggravated: proteinuria re-absorption of a large number of proteins in each digest extra energy can cause tubular cell hypoxia, resulting in the tubule cell injury.

What triggered a chronic kidney disease?

Kidney damage and decreased function lasting longer than 3 months is called chronic kidney disease(CKD).Chronic kidney disease is particularly dangerous since you may not have any symptoms until considerable, often irreparable, kidney damage has been done.
Diabetes and high blood pressure are the most common causes of chronic kidney disease (CKD).
Diabetes, both type 1 and type 2 diabetes, can damage the kidneys, with a loss of kidney function that is often progressive over time.Medical care can slow, but not reverse, this kidney damage. Diabetes is a leading reason why people need dialysis or a kidney transplant.
Type 1 and type 2 diabetes mellitus cause a condition called diabetic nephropathy, which is the leading cause of kidney disease in the United States.
High blood pressure (hypertension), if not controlled, can damage the kidneys over time.
Glomerulonephritis is the inflammation and damage of the filtration system of the kidneys, which can cause kidney failure. Postinfectious conditions and lupus are among the many causes of glomerulonephritis.
Polycystic kidney disease is an example of a hereditary cause of chronic kidney disease wherein both kidneys have multiple cysts.
Many people who have chronic kidney disease don't know it, because the early signs can be very subtle. It can take many years to go from chronic kidney disease (CKD) to kidney failure. Some people with CKD live out their lives without ever reaching kidney failure.

A 50 Year-Old Renal Insufficiency Patient Recovers

Two years ago, Mr Wang got a cold in winter, and found protein in urine. Then, he went to the local hospital and was diagnosed with chronic kidney disease. Through another examination, he also was told to have high blood pressure. What’s worse, high blood pressure has lasted for 8 years, which caused kidney disease. So with doctor’s guidance, he took treatment, which was mainly about western medicine and western therapy. Two months later, after an examination, the report showed the protein in urine was negative, so he discharge from the local hospital and went on to work again.
Unfortunately, four months ago, due to being tired and getting a cold, Mr Wang got sick again. He went to Kidney Disease Hospital. Before discharging in our hospital, he had a series of physical examination.
The report was as follows: oliguria, edema in legs, blood pressure: 170/95mmHg. The eyelids had edema as well. Renal function examination showed that BUN:18mmol/L, Cr:387umol/L, UA 700umol/L, Hb80g/L, protein in urine: two pluses. The B ultrasound showed that the two kidney shrinked. So he was diagnosed with Renal Failure with high blood pressure.

Chronic Kidney Disease Caused by Diabetic Nephropathy

At present, it is generally believed that Chronic Kidney Disease caused by Diabetic Nephropath has many causes including metabolism disorder, abnormal secretion, haemodynamics change and capillaries change. It is said that the coming into being of Chronic Kidney Disease caused by Diabetic Nephropath is connected with gene, insulin, glucagon, abnormal growth hormone enlarged kidney. The majority hold the idea that metabolism disorder influences the basilar, and makes their elements change. So the basilar membrane increases and the permeability of capillaries become width. In this case, Chronic Kidney Disease caused by Diabetic Nephropath comes into being.
Chronic Kidney Disease caused by Diabetic Nephropath is a common complication of Diabetes. 15% of patients with type 2 Diabetes are likely to suffer from Chronic Kidney Disease caused by Diabetic Nephropath. In recent years, more younger people tend to have Chronic Kidney Disease caused by Diabetic Nephropath. So effective treatment is necessary or else it may develop into renal failure.

Suggestions to People with Chronic Kidney Disease

As Chronic Kidney Disease is not easy to be found in the early stage, so some people usually are diagnosed with early kidney failure once there are some obvious symptoms. With damaged kidneys, do you know what you should attach importance to? If no, please have a look about the following several suggests which may go a long way towards helping control your disease.

Suggestion one: People with Chronic Kidney Disease obviously have large amount of proteinuria. Our body needs protein every day for growth, building muscles and repairing tissues. After our body uses the protein ingested by us in the diet, urea which is a waste product will be made. For people with Chronic Kidney Disease, their kidneys may not be able to get rid of these waste products smoothly. Therefore, people with Chronic Kidney Disease may need to reduce the amount of protein they ingest to avoid the buildup of urea in their body.

Suggestion two: As kidneys are damaged, people suffering from Chronic Kidney Disease should limit the intake of phosphorus as well. Normally, extra phosphorus is removed by our kidneys and since kidneys lose the excretion ability, then the level of phosphorus in our blood will become high. High level of phosphorus will cause us to lose calcium from our bones and make them break easily. Therefore, to strengthen their body, people with Chronic Kidney Disease should avoid ingesting too much phosphorus.

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High blood pressure and Chronic Kidney Disease

High blood pressure is the second leading cause of CKD. If you have high blood pressure and it goes untreated, blood vessels throughout your body can be damaged. When your kidneys’ blood vessels are damaged, their ability to remove waste and excess fluids from your body is impaired and serious health issues can occur. In addition, the extra fluid in your blood can cause your blood pressure to go up even higher, creating a dangerous cycle. Increased blood pressure due to kidney changes is referred to as kidney disease hypertension
Diagnosing high blood pressure
There are no obvious symptoms of high blood pressure or hypertension, so it can go unnoticed and cause damage before it is diagnosed. That’s why it’s critical that you have your blood pressure checked regularly by your doctor. You can also learn to take your blood pressure at home or at your local pharmacy for more frequent readings. For the most accurate reading, blood pressure should be checked in a quiet room after you’ve been sitting still for at least five minutes.
Maintain your weight at a level appropriate for you height.
Eat fresh fruits and vegetables, whole grains and low-fat dairy foods .
Limit your daily sodium intake to 2,000 milligrams.
Exercise at a moderate level for 30 minutes almost every day.
Avoid consuming too much alcohol. Men should have no more than two drinks per day, and women no more than one drink per day.
Do not smoke.
Along with a healthy lifestyle, you may need medication to control your blood pressure. The most common types of blood pressure medications are diuretics, angiotensin-converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), beta blockers and calcium channel blockers. Studies have shown that ACE inhibitors and ARBs protect the kidneys and slow the progression of chronic kidney disease.
High blood pressure is one of the leading causes of kidney failure, also called end stage renal disease (ESRD), or Stage 5 chronic kidney disease. People at this stage must either receive a kidney transplant or have regular blood-cleansing treatments called dialysis. To prevent kidney failure, it is important to take every measure to maintain your blood pressure at the recommended levels. It is necessary for you to learn all about your treatments, and work with your doctor and other health care practitioners to help you achieve your health goals.