In the early stage of Diabetic Nephropathy, there are no obvious symptoms and the blood pressure maybe high or normal. The morbidity of Diabetic Nephropathy changes with the extension of the course of Diabetes. Then what are the root causes of Diabetic Nephropathy?
● Genetic Factor.
Genetic factor is the one of the causes of this kind of renal disease. For patients with Diabetes, most of them will not have renal damage finally. However, for these who have controlled their blood sugar, they also have the possibility to get Diabetic Nephropathy and this is cased by the genetic factor.
● Hyperglycemia.
The occurrence of Diabetic Nephropathy has close relationship with hyperglycemia. Bad control of blood sugar will accelerate the appearance of Diabetic Nephropathy, while, the better control will help to delay the development of this disease. Both high blood sugar and increase of the advanced glycation end products can give rise to the increase of mesangial cell, extracellular matrix as well as the incrassation of glomerular basilar membrane.
● High Blood Pressure.
High blood pressure has no direct relationship with the occurrence of Diabetic Nephropathy. However, the increase of blood pressure can promote the excretion of urine albumin, leading to the aggravation of Diabetic Nephropathy.
