Iga nephritis development for renal failure

Many kidney patients for the first time to the hospital, there are already more than two-thirds of the human kidney does not function properly, a quarter of patients the disease has advanced to the late.
Kidney disease began often no symptoms when kidney damage is greater than 75%, to appear in patients with anemia, fatigue, nausea, vomiting, abdominal distension, anorexia, hypertension, population Niaowei, dark skin and hair scorch . When most people would go to the hospital, but often do not know Behold Division, had to look good appetite Gastroenterology, anemia go Hematology, few people think of their kidneys has gone wrong.
iga nephritis may develop kidney failure you? In China, the majority of renal failure, that is, uremia are caused by nephritis, renal failure caused by hypertension, diabetes and other diseases are also increasing.
40% of people with diabetes, if you do not control and treatment, will ultimately kidney damage situation, of which 10% will lead to renal failure. Hypertension, diabetes, high blood lipids and obesity by controlling blood pressure, blood sugar, blood lipids and body weight, fully control the occurrence of chronic kidney disease.
Suffering from nephritis, patients with early stage only the clinical symptoms of proteinuria, and occult, and other special aspects of the symptoms. But this is not the function of the kidney is still intact, renal parenchymal damage. A variety of pathogenic causes of Renal cell damage and the release of a series of inflammatory mediators in the inflammatory response, cell activity increased with the severity of cell damage, cell phenotypic conversion to occur, the cells begin to harden, the beginning of the renal loss.
When the degree of loss of less than 50%, that is, cell hardening has not yet more than half of the patients with no clinical indicators of change, it is clear, still in the normal range of serum creatinine or blood urea nitrogen, no symptoms, but the kidney that the fibrosis has been started. Healthy kidney units less than 20%, nephritis in patients with renal function abnormalities revealed abnormalities not only reflected in the indicators and symptoms of acidosis, the disease progression to renal failure.
When more than 90% of renal cell fibrosis, severe metabolic acidosis symptoms, heart, brain and other deterioration symptoms, enter the end stage renal failure - uremia.