As glomerular filtration membrane permeability changes, increased protein
swim, forming massive proteinuria. Glomerular filtration membrane permeability
changes, and pathological changes in addition to the outside, but still with
glomerular epithelial cell membrane surface charge change.
Application of glucocorticoids in the treatment of nephrotic syndrome is a hormone indispensable part, using it to treat a certain extent, ease the patient's pain, improve short-term effect, however, there is no control of hormone application as if opened the "Pandora's box", bring happiness to people, but also attracted a disaster, so that patients with a variety of irreversible severe symptoms:
A long-term super-physiological doses of glucocorticoid can cause water, salt, sugar, protein and fat metabolism disorders, hyperthyroidism adrenal class. Manifested as central obesity, resulting in malabsorption of calcium, resulting in osteoporosis, severe cases can occur spontaneous fractures.
2, corticosteroids can weaken the body's defense ability of the disease, is conducive to bacterial growth and reproduction and proliferation, induce or aggravate infection.
3, glucocorticoids promote protein degradation, can delay the formation of granulation tissue, hinder trauma or surgical wound and other ulcer healing.
4, glucocorticoids have against the role of growth hormone, children's long-term use can inhibit bone growth and protein synthesis, affecting growth and development, pregnant women can cause fetal malformations application.
5, long-term glucocorticoid therapy, after controlling the symptoms, such as weight loss fast or abrupt withdrawal, the original symptoms may occur or worsen rapidly, known as the "rebound phenomenon." Some had no symptoms of the disease, such as muscle pain, muscle stiffness, joint pain, called withdrawal symptoms (also known as withdrawal syndrome).
In addition, long-term use of corticosteroids can cause adrenal cortical atrophy or dysfunction, induce and aggravate ulcers and even cause neuropsychiatric symptoms caused great obstacle for the rehabilitation of patients.
Overall, hormone therapy is just a mere formality, and does not solve the real problem, made a "stop-gap" taboo, so the application must be adequate hormone, not blindly pursue hormone treatment rather large number of applications, Patients also can not just stare at the laboratory markers in the treatment direction into errors.
Application of glucocorticoids in the treatment of nephrotic syndrome is a hormone indispensable part, using it to treat a certain extent, ease the patient's pain, improve short-term effect, however, there is no control of hormone application as if opened the "Pandora's box", bring happiness to people, but also attracted a disaster, so that patients with a variety of irreversible severe symptoms:
A long-term super-physiological doses of glucocorticoid can cause water, salt, sugar, protein and fat metabolism disorders, hyperthyroidism adrenal class. Manifested as central obesity, resulting in malabsorption of calcium, resulting in osteoporosis, severe cases can occur spontaneous fractures.
2, corticosteroids can weaken the body's defense ability of the disease, is conducive to bacterial growth and reproduction and proliferation, induce or aggravate infection.
3, glucocorticoids promote protein degradation, can delay the formation of granulation tissue, hinder trauma or surgical wound and other ulcer healing.
4, glucocorticoids have against the role of growth hormone, children's long-term use can inhibit bone growth and protein synthesis, affecting growth and development, pregnant women can cause fetal malformations application.
5, long-term glucocorticoid therapy, after controlling the symptoms, such as weight loss fast or abrupt withdrawal, the original symptoms may occur or worsen rapidly, known as the "rebound phenomenon." Some had no symptoms of the disease, such as muscle pain, muscle stiffness, joint pain, called withdrawal symptoms (also known as withdrawal syndrome).
In addition, long-term use of corticosteroids can cause adrenal cortical atrophy or dysfunction, induce and aggravate ulcers and even cause neuropsychiatric symptoms caused great obstacle for the rehabilitation of patients.
Overall, hormone therapy is just a mere formality, and does not solve the real problem, made a "stop-gap" taboo, so the application must be adequate hormone, not blindly pursue hormone treatment rather large number of applications, Patients also can not just stare at the laboratory markers in the treatment direction into errors.
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