Renal diabetes caused by many factors, most important of which is sodium retention lead to increased blood volume and the renin-angiotensin system, the enhanced role. Diabetic kidney is divided into two kinds of capacity-dependent diabetes mellitus and renin-dependent diabetes. Capacity-dependent diabetes mellitus is renal parenchymal disease, the kidneys lose the body excrete water and salt effect, resulting in sodium and water retention in the body, so that the blood volume increase caused by diabetes. Vascular smooth muscle cells within the Shuinazhuliu allows sodium and water content increased vessel wall thickening and elasticity decreased vascular resistance and reactivity enhancement of catecholamines, and angiotensin II on vascular receptor affinity to improve, and would also make the blood pressure increased. Renin-dependent diabetes mellitus is due to renal artery stenosis, renal parenchymal disease, as well as the secretion of renin-cell tumors, resulting in renin release a large number, causing increased activity of angiotensin Ⅱ systemic arteriole contraction. Renin and angiotensin II but also to promote the increase in aldosterone secretion, lead to sodium retention, blood volume increase resulting from diabetes. Renal other antihypertensive substances decreased release of activity decreased; increased sympathetic activity, systemic small artery spasm, hypertensive, diabetic important factor.
