Deteriorating from all types of early chronic kidney disease progressed to
renal insufficiency, renal failure stage, the most typical and representative
characteristics of serum creatinine is elevated. However, for such most of the
crowd, they often do not know, creatinine how elevated. The resort is constantly
changing variety of drug treatment to reduce creatinine. The result of this
situation is that patients with renal failure during treatment of recurrent
disease, or creatinine constantly rose, his condition continued to deteriorate
progress. In this regard, the guidance of professional doctors: lower serum
creatinine, we must first understand the reasons for the formation of
creatinine, and understand the focus of renal failure in the treatment of
disease, standard treatment in order to inhibit the progress of the disease.
Here we talk about the reasons for the formation of creatinine and creatinine
values, the significance of treatment for patients with renal failure. A
creatinine is formed? Patients with nephropathy due to various primary,
secondary etiology, leading to glomerular local microcirculation, ischemia and
hypoxia phenomenon of Renal cell damage occurred in the stimulation of the
inflammatory response, renal intrinsic cells gradually damage apoptosis,
resulting in most of the glomerular fibrosis gradually hardening, kidney overall
decline in filtration rate, resulting in creatinine can not be discharged, tests
found elevated creatinine. In addition, because patients have entered the renal
failure, renal fibrosis and spread to the whole kidney, renal intrinsic cells in
the stimulation of a variety of pathogenic factors, phenotypic change to
myofibroblasts, the secretion of synthesized a series of difficult to be
degraded extracellular matrix, extracellular matrix increased to replace the
normal, healthy kidney function units, gradually lost due to renal excretory
function decline, which also resulted in serum creatinine can not be discharged,
elevated serum creatinine. (2) renal failure, initial treatment, creatinine why
only l did not fall? We all know that kidney disease is a chronic disease, it is
not one or two days in the rehabilitation course, in a short time is
unrealistic. Patients with renal insufficiency has been a lot of inherent cell
damage in the kidney, and not susceptible to degradation of extracellular matrix
increased, which resulted in the retention of creatinine in the blood, there
creatinine rise. And the progress of the disease along with the late, creatinine
increase speed gradually speed up, even though we applied traditional Chinese
medicine the kidney area iontophoresis, but still keep up with the speed of its
progress within 20 days of the effective time, can only inhibit the progress of
the disease, slow creatinine rise. Of course, this is only for a stage,
gradually play with the drug pharmacodynamics intrinsic cells of the kidney
damage also gradually restored to function after the system nursed back to
health and medication, serum creatinine naturally will slowly decline until last
stable normal. It needs our attention, that is, each patient and each individual
patient constitution and disease progress, so the difference in the treatment
time and the effect, but as long as we choose the right therapy and timing of,
and adhere to a certain period medicine and science at home maintenance, and
repair of the kidney is only a matter of time. Nephropathy hospital director of
the kidney specialists warned friends being treated for renal failure patients,
the course of treatment, especially early in treatment can not simply look at
indicators, including not only creatinine, including urinary protein, occult
blood, and other indicators of kidney disease early. Because not only to cure
disease, but also to cure, while the treatment is the most critical and
important.
